An injured, infected, inflamed or diseased patch of skin.

“They put ointment and a bandage on the sore.”

Grief; affliction; trouble; difficulty.

To mutilate the legs or feet of (a horse) in order to induce a particular gait.

Causing pain or discomfort; painfully sensitive.

“Her feet were sore from walking so far.”

Sensitive; tender; easily pained, grieved, or vexed; very susceptible of irritation.

Dire; distressing.

“The school was in sore need of textbooks, theirs having been ruined in the flood.”

Very, excessively, extremely (of something bad).

Sorely.