noun

1. Loss of hope; utter hopelessness; complete despondency.

   “He turned around in despair, aware that he was not going to survive”

2. That which causes despair.

3. That which is despaired of.

Synonyms: desperation, despondency, hopelessness

verb

1. To give up as beyond hope or expectation; to despair of.

2. To cause to despair.

3. (often with “of”) To be hopeless; to have no hope; to give up all hope or expectation.