Someone with exceptional skills in a certain field.

“She sure was a hotshot on the keyboard, 93 words per minute!”

A type of firefighter highly skilled in wildfire firefighting without external support, using basic tools that are backpacked in and manhandled about.

A fast freight train.

To give (somebody) a dose of recreational drugs deliberately laced with poison.

Highly skilled.

“He was a hotshot lawyer, with an astounding win-loss record.”

Displaying talent.

“Keep up those hotshot baskets, the scouts are sure to take notice.”