A hardened area of the skin (especially on the foot or hand) caused by repeated friction, wear or use.

The material of repair in fractures of bone; a substance exuded at the site of fracture, which is at first soft or cartilaginous in consistency, but is ultimately converted into true bone and unites the fragments into a single piece.

The new formation over the end of a cutting, before it puts out rootlets.

To form such hardened tissue.