A negative aspect; a downer.

“I love almost everything about my job. The only down is that I can't take Saturdays off.”

A grudge (on someone).

An act of swallowing an entire drink at once.

To knock (someone or something) down; to cause to come down, to fell.

“A single rifle shot downed the mighty beast.”

To lower; to put (something) down.

“The bell rang for lunch, and the workers downed their tools.”

To defeat; to overpower.

Sad, unhappy, depressed, feeling low.

“Mary seems very down since she split up with her boyfriend.”

(normally in the combination 'down with') Sick or ill.

“He is down with the flu.”

At a lower level than before.

“Prices are down.”

From a higher position to a lower one; downwards.

“The cat jumped down from the table.”

At a lower or further place or position along a set path.

“His place is farther down the road.”

South (as south is at the bottom of typical maps).

“I went down to Miami for a conference.”

From the higher end to the lower of.

“The ball rolled down the hill.”

From nouth to south of.

“We sailed down the eastern seaboard.”

From one end to another of (in any direction); along.

“The bus went down the street.”