Bile, especially that of an animal; the greenish, profoundly bitter-tasting fluid found in bile ducts and gall bladders, structures associated with the liver.

The gall bladder.

Great misery or physical suffering, likened to the bitterest-tasting of substances.

To bother or trouble.

To harass, to harry, often with the intent to cause injury.

To chafe, to rub or subject to friction; to create a sore on the skin.